From St. Louis County, Missouri
Take I-270 to MO-370 west.  Exit onto Missouri Highway 94 north, just past the Missouri River bridge.  There is a stoplight at the bottom of the exit ramp; turn left to go north on MO-94.  Take 94 north seven miles to Grafton Ferry Road and turn left.  Be aware, the turn is easy to miss.  Take Grafton Ferry Road three miles south, past St. Charles County Smartt Field Airport, and turn left at the last road before the river.  The Grafton Ferry Missouri Landing is 100 feet ahead on the right.

From St. Charles, St. Peters and points west
Take I-70 to MO-370 east.  Exit onto MO-94 north.  Follow the directions above to the Grafton Ferry Missouri Landing.

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From points east/southeast in Illinois
Take I-270 west to Illinois Route 3.  Take Route 3 north to IL Route 143 and merge left.  Take Route 143 north/northwest to a stoplight at the Clark Bridge in Alton, where 143 becomes Landmarks Boulevard.  Continue through two more stoplights: Argosy's Alton Belle Casino will be on your left.  Bear left approaching the next traffic light at the intersection of IL Route 100; the Alton Visitor's Center is located on the northwest corner.  Turn left (west) to leave Alton and follow the beautiful Meeting of the Great Rivers Scenic Route (Route 100, "The Great River Road")  west along the Mississippi River for 12 miles.  You'll pass Clifton Terrace, Piasa Harbor, Elsah and Chautauqua.  Grafton city limits start at the Palisades and Raging Rivers WaterPark.  The speed limit drops from 55 to 50 MPH at the city limits, and drops again to 40 MPH at the Visitor's Center.  Just before entering downtown Grafton, the speed limit drops to 30 MPH, and the Scenic Byway becomes Grafton's Main Street.  Continue on Main Street for five blocks to the intersection of Route 3 or Market Street; Uncle Andy's Produce is on the southeast corner, Jersey State Bank is on the northeast corner, and Grove Memorial Park is northwest.  Turn left (south) on Market Street and go one block to the Grafton Ferry parking lot entrance on the right side of the road.

From Springfield, Chicago and points north/northeast in Illinois
Take I-55 south to IL Route 16 at Litchfield.  Take Route 16 west to IL Route 267/US 67 in Jerseyville.  Turn left on Jerseyville's State Street (US 67) and head south a few blocks to the IL Route 109 junction.  Take Route 109 south/southeast to its end at the IL Route 3 junction and turn right.  The signs read "3 NORTH", but you'll be traveling due west.  Continue west/southwest on Route 3 to its end at the Scenic Byway/Main Street in Grafton.  Continuing south, cross Main Street and go one block to the Grafton Ferry parking lot entrance on the right side of the road.